Research Progress in the Therapeutic Strategy Based on Targeting at
Lung Cancer Stem Cell.
10.3779/j.issn.1009-3419.2018.01.08
- Author:
Hongjin LAI
1
;
Feng LIN
2
;
Nan CHEN
1
;
Shu WEN
2
;
Xiao HU
3
;
Lunxu LIU
2
Author Information
1. West China School Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
2. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
3. Department of Thoracic Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
- Publication Type:Journal Article
- Keywords:
Lung cancer stem cells;
Lung neoplasms;
Molecular targeted therapy;
Neoplastic stem cells
- MeSH:
Animals;
Humans;
Lung Neoplasms;
drug therapy;
pathology;
Molecular Targeted Therapy;
methods;
Neoplastic Stem Cells;
drug effects;
pathology;
Signal Transduction;
drug effects
- From:
Chinese Journal of Lung Cancer
2018;21(1):57-62
- CountryChina
- Language:Chinese
-
Abstract:
With high morbidity and mortality, lung cancer is a major threat to human health and one of the focuses of tumor researches. Lung cancer stem cells (LCSCs) are regarded as a subpopulation of cells within lung cancer tissues with the capacity of self-renewal and differentiation, and might be related to tumorigenesis and heterogeneity of lung cancer. Tumor recurrence, metastasis and drug resistance of lung cancers could be clarified by LCSC hypothesis. Thus it's therapeutically prospective to target at these cells. This review summarizes the biomarkers of LCSCs and their aberrant signal pathways, as well as the therapeutic strategies targeting at LCSCs.
