Research Advances of Pan-negative Type of Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2018.02.07
- VernacularTitle:Pan-negative型非小细胞肺癌的研究进展
- Author:
Li SUN
1
;
Zhicheng XIONG
1
;
Chengbo HAN
1
Author Information
1. Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China.
- Publication Type:Journal Article
- Keywords:
Driver gene;
Lung neoplasms;
Pan-negative
- MeSH:
Carcinoma, Non-Small-Cell Lung;
diagnosis;
drug therapy;
genetics;
pathology;
Humans;
Lung Neoplasms;
diagnosis;
drug therapy;
genetics;
pathology;
Mutation;
Prognosis
- From:
Chinese Journal of Lung Cancer
2018;21(2):129-138
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, series of driver genes, such as EGFR, KRAS/NRAS, BRAF, PIK3CA, ALK and ROS1 and so on, have been found in non-small cell lung cancer (NSCLC) one after another with the development of molecular detecting technology. Targeted drugs bring benefits for these NSCLC patients with driver gene variations. However, some NSCLC did not have any known driver gene variations; we called it pan-negative lung cancer. In this paper, we summarize the concept, clinical pathological characteristics, the epidemiological characteristics, treatment and prognosis of pan-negative NSCLC.
