The Clinical and Molecular Characteristics of Adenocarcinoma Presented
by Multi-focal GGO.
10.3779/j.issn.1009-3419.2018.03.07
- Author:
Yang SONG
1
;
Naixin LIANG
1
;
Shanqing LI
1
Author Information
1. Department of Thoracic Surgery, Chinese Academy of Medical Sciences & Peking Union Medical Colledge Hospital, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
EGFR;
Genetic heterogeneity;
Multiple primary lung cancer;
Spread through air spaces (STAS)
- MeSH:
Adenocarcinoma;
diagnostic imaging;
genetics;
pathology;
Adenocarcinoma of Lung;
Humans;
Lung Neoplasms;
diagnostic imaging;
genetics;
pathology;
Retrospective Studies;
Solitary Pulmonary Nodule;
diagnostic imaging;
genetics;
pathology;
Tomography, X-Ray Computed
- From:
Chinese Journal of Lung Cancer
2018;21(3):163-167
- CountryChina
- Language:Chinese
-
Abstract:
Due to emphasis on early screening for lung cancer, the detection rate of multiple ground glass opacities (GGOs) on computed tomography (CT) image increases in recent years, and research on multifocal adenocarcinomas presented by GGOs has been thriving. It is more common in women and non-smokers and has excellent prognosis both in patients with natural history and after surgery. These clinical features suggest that it is likely to be a distinct disease entity. From the perspective of molecular genetics, lesions in the same individual are likely to have distinct clonal features. Therefore, genetic heterogeneity is the most prominent feature of multifocal pulmonary adenocarcinomas with GGOs. The genetic heterogeneity is expected to assist the diagnosis of multifocal pulmonary adenocarcinoma and intrapulmonary metastasis, and also suggests that genetic testing of the GGO lesions is of great therapeutic significance. Some GGO lesions may harvest the similar clonal feature, which provide new evidence for the theory of spread through air spaces (STAS).
.
