Relationship between FGFR1 Gene Regulation of Circulating Tumor Cells and Clinical Features of Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2018.05.03
- Author:
Lei LIU
1
;
Cheng HUANG
2
;
Li LI
2
;
Naixin LIANG
2
;
Shanqing LI
2
Author Information
1. Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
2. Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
Circulating tumor cell;
Fibroblast growth factor receptor 1;
Lung neoplasms;
Metastasis;
Smoking history
- MeSH:
Adult;
Carcinoma, Non-Small-Cell Lung;
genetics;
metabolism;
Female;
Humans;
Lung Neoplasms;
genetics;
metabolism;
Male;
Middle Aged;
Neoplastic Cells, Circulating;
metabolism;
Receptor, Fibroblast Growth Factor, Type 1;
genetics;
metabolism;
Young Adult
- From:
Chinese Journal of Lung Cancer
2018;21(5):365-374
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The methods of detection for recurrence and metastasis in patients with non-small cell lung cancer (NSCLC) have hysteresis and one-sidedness. This study summarizes the relationship between the circulating tumor cell (CTC) in peripheral blood, expression of fibroblast growth factor receptor 1 (FGFR1) and clinic pathological features in 30 patients with NSCLC so as to provide new ideas for the detection of tumor recurrence and metastasis.
METHODS:To analyze the clinical data and CTC detection data of 30 cases of NSCLC in Department of Thoracic Surgery, Peking Union Medical College Hospital from November 2016 to June 2017.
RESULTS:Data analysis showed that the positive rate of CTC in peripheral blood was remarkably correlated with the smoking history (P=0.016). There was no significant correlation among the pathological type and CTC positive rate and the expression of FGFR1 (P=0.202, P=0.806). There was no significant difference in the expression of FGFR1 in different type CTC cells (P=0.094).
CONCLUSIONS:The positive rate of CTC was significantly correlated with the smoking history of patients with NSCLC. There was no significant difference in CTC classification and FGFR1 expression in different pathological types of NSCLC. There was no significant difference in the expression of FGFR1 between different types of CTCs. We look forward to a larger sample size and inclusion of follow-up data to arrive at more clinically relevant conclusions about CTC and FGFR1 gene expression.
