Functions of lamin B1 and the new progress of its roles in neurological diseases and tumors.

Author: Siyang LIU ¹ ; Yong WU ¹ ; Linfei YANG ² ; Xiaohua LI ² ; Lihua HUANG ² ; Xiaowei XING ²
Author Information

1. Department of Clinical Laboratory, the Third Xiangya Hospital of Central South University, Changsha 410013, Hunan, China.
2. Center for Experimental Medicine Research, the Third Xiangya Hospital of Central South University, Changsha 410013, Hunan, China.
Publication Type:Journal Article
Keywords: cell activity; lamin B1; neural tube defects; nucleoskeleton; tumor
MeSH: Cell Nucleus; Gene Expression; Humans; Lamin Type B; physiology; Neoplasms; Nervous System Diseases
From: Chinese Journal of Biotechnology 2018;34(11):1742-1749
CountryChina
Language:Chinese
Abstract: Lamin B1 is one of the essential members of the nuclear lamina protein family. Its main function is to maintain the integrity of nuclear skeleton, as well as to participate in the cell proliferation and aging by affecting the chromosome distribution. gene expression, and DNA damage repair. The abnormal expression of lamin B1 is related to certain diseases, including neurological diseases [e.g. neural tube defects (NDTs), adult-onset autosomal dominant leukodystrophy (ADLD)] and tumors (e.g. pancreatic cancer). It is also a potential tumor marker as well as drug target. Further research on lamin B1 will help people understand the molecular mechanism of the emergence and development of neural system diseases and tumors, and define a new future in drug target.