Observation on therapeutic effect and mechanism research of acupuncture on headache in the recovery phase of ischemic stroke.
10.13703/j.0255-2930.2019.11.003
- Author:
Hua DONG
1
;
Hong-Yi ZHAO
1
;
Jian-Wu WANG
1
;
Jing-Xian HAN
1
Author Information
1. Department of Tuina, First Teaching Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China.
- Publication Type:Journal Article
- Keywords:
acupuncture;
endogenous opioid peptides;
headache;
ischemic stroke;
pain-related factors
- MeSH:
Acupuncture Points;
Acupuncture Therapy;
methods;
Brain Ischemia;
Flunarizine;
therapeutic use;
Headache;
therapy;
Humans;
Stroke;
complications;
Treatment Outcome;
Vasodilator Agents;
therapeutic use
- From:
Chinese Acupuncture & Moxibustion
2019;39(11):1149-1153
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical therapeutic effect and mechanism of acupuncture on headache in the recovery phase of ischemic stroke.
METHODS:A total of 97 patients with headache in the recovery phase of ischemic stroke were randomized into an acupuncture group (57 cases) and a western medication group (40 cases). In the western medication group, flunarizine hydrochloride capsule was taken orally 5 mg each time, once a day. In the acupuncture group, acupuncture was applied at Qiuxu (GB 40), Zulinqi (GB 41), Xuanli (GB 6), Shuaigu (GB 8), Fengchi (GB 20) and Baihui (GV 20) for migraine; Chongyang (ST 42), Neiting (ST 44), Jiexi (ST 41), Zusanli (ST 36), Hegu (LI 4), Cuanzhu (BL 2) and Baihui (GV 20) for forehead pain; Jinggu (BL 64), Kunlun (BL 60), Tianzhu (BL 10), Fengchi (GB 20), Baihui (GV 20) and Sishencong (EX-HN 1) for occipital headache; Taichong (LR 3), Yongquan (KI 1), Sanyinjiao (SP 6), Fengchi (GB 20), Baihui (GV 20) and Sishencong (EX-HN 1) for parietal headache. The needles were retained for 30 min each time, once a day and 5 times a week. Both of the two groups were given consecutive treatment for 14 days. The visual analogue scale (VAS) and the headache scores before and after treatment and the recurrence rate 1 month after treatment were observed to evaluate the therapeutic effect, before and after treatment, the contents of substance P (SP), dopamine (DA), serotonin (5-HT), alpha-endorphin (α-EP) and beta-endorphin (β-EP) in plasma were determined by ELISA in the two groups.
RESULTS:Compared before treatment, the VAS scores, the headache scores and the contents of SP, DA and 5-HT in plasma were reduced and the contents ofα-EP andβ-EP in plasma were increased in the two groups (all <0.01). After treatment, the changes of the VAS score, the headache score and the contents of pain-related factors and endogenous opioid peptides in plasma in the acupuncture group were larger than the western medication group (all <0.05). The total effective rate in the acupuncture group was 84.2% (48/57), which was superior to 62.5% (25/40) in the western medication group, and the recurrence rate in the acupuncture group was lower than the western medication group (both <0.01).
CONCLUSION:The therapeutic effect of acupuncture on headache in the recovery phase of ischemic stroke is superior to flunarizine hydrochloride capsule, and the mechanism may relate to down-regulate the pain-related factors and up-regulate endogenous opioid peptides in plasma.
