Research status of correlation between type IX collagen gene and musculoskeletal diseases.
10.3969/j.issn.1003-0034.2019.01.021
- Author:
Rui DONG
;
Yun-Yao WU
;
Liang FANG
;
Jun YING
;
Lei ZHANG
;
Shi-Bing XU
;
Ping-Er WANG
;
Hong-Ting JIN
;
Lu-Wei XIAO
;
Pei-Jian TONG
1
,
2
Author Information
1. The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
2. tongpeijian@163.com.
- Publication Type:Journal Article
- Keywords:
Cartilage;
Collagen type IX;
Genes;
Review
- MeSH:
Cartilage, Articular;
Collagen;
Collagen Type IX;
Humans;
Intervertebral Disc Degeneration;
Musculoskeletal Diseases
- From:
China Journal of Orthopaedics and Traumatology
2019;32(1):92-96
- CountryChina
- Language:Chinese
-
Abstract:
As an important component of articular cartilage, type IX collagen plays an important role in regulating homeostasis of bone and cartilage. The mutation or deletion of gene could disequilibrate homeostasis leads to deformity of corresponding bone and joint, and finally causes multiple epiphyseal dysplasia. Moreover, anatomic variation also leads to biomechanics change of corresponding functional unit, combine with micro-environment change caused by change of genes, osteoarthritis and disc degeneration were occurred under the function of stress over and over again. In addition, lack of type IX collagen could effect repair of articular cartilage, intervertebral disc tissue injury. However, musculoskeletal diseases related with type IX collagen has so much not limited this, the reports about it is less for lack of evidence, and need further work to study. Clear relationship of type IX collagen and its disease could provide an effective diagnostic method, and develop a new pathway for follow-up treatment.
