Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes.

Di CHENG; Rui DU; Xue Yan WU; Lin LIN; Kui PENG; Li Na MA; Yu XU; Min XU; Yu Hong CHEN; Yu Fang BI; Wei Qing WANG; Meng DAI; Jie Li LU

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Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes.

Author: Di CHENG ¹ ; Rui DU ¹ ; Xue Yan WU ¹ ; Lin LIN ¹ ; Kui PENG ¹ ; Li Na MA ¹ ; Yu XU ¹ ; Min XU ¹ ; Yu Hong CHEN ¹ ; Yu Fang BI ¹ ; Wei Qing WANG ¹ ; Meng DAI ¹ ; Jie Li LU ¹
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1. National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.
Publication Type:Journal Article
Keywords: Atherosclerotic cardiovascular diseases; Cardiovascular disease; Framingham risk score; Uric acid
MeSH: Biomarkers; blood; Blood Glucose; analysis; Blood Pressure; Body Mass Index; China; Coronary Disease; blood; epidemiology; Cross-Sectional Studies; Female; Glycated Hemoglobin A; analysis; Humans; Lipids; blood; Male; Middle Aged; Predictive Value of Tests; Prevalence; Risk Factors; Sex Factors; Uric Acid; blood
From: Biomedical and Environmental Sciences 2018;31(2):106-114
CountryChina
Language:English
Abstract: OBJECTIVE:To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes.
METHODS:We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases (ASCVD) among 8,252 participants aged ⪖ 40 years without diabetes from Jiading district, Shanghai, China.
RESULTS:Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid (all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia (all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios (ORs) [95% confidence intervals (CIs)] for the highest quartiles for high Framingham risk were 3.00 (2.00-4.50) in men and 2.95 (1.08-8.43) in women. The multivariate adjusted ORs (95% CIs) for the highest quartile for high ASCVD risk were 1.93 (1.17-3.17) in men and 4.53 (2.57-7.98) in women.
CONCLUSION:Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes.