Research Advances in Mitogen-activated Protein Kinases in Central and Peripheral Sensitization of Diabetic Neuropathic Pain.
10.3881/j.issn.1000-503X.10396
- Author:
Xin ZHANG
1
;
Le SHEN
1
;
Yu Guang HUANG
1
Author Information
1. Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- MeSH:
Animals;
Diabetic Neuropathies;
Ganglia, Spinal;
Mitogen-Activated Protein Kinases;
Neuralgia;
p38 Mitogen-Activated Protein Kinases
- From:
Acta Academiae Medicinae Sinicae
2019;41(1):118-123
- CountryChina
- Language:Chinese
-
Abstract:
Mitogen-activated protein kinases(MAPKs)are Ser/Thr kinases consisting of extracellular regulated protein kinases(ERK)1/2,c-Jun N-terminal kinase 1/2/3,p38 isoforms(α,β,γ,and δ),and ERK5,which mediate a range of cellular activities including proliferation,differentiation,apoptosis,immunity,and inflammation. Pain sensitization is a remodeling mechanism of central and peripheral nociceptor. A growing number of evidences have indicated that MAPKs are extensively activated in the spinal dorsal cord and dorsal root ganglions in the animal models of diabetic neuropathic pain(DNP)and play an important role in the central and peripheral sensitization of DNP. In addition,some drugs can alleviate DNP by suppressing MAPKs activation of central and peripheral nervous system. This article summarizes the research progress of MAPKs in central and peripheral sensitization of DNP.
