Associations of Non-alcoholic Fatty Liver Disease with Prevalence,Severity,and Prognosis of Coronary Heart Disease.
10.3881/j.issn.1000-503X.10512
- Author:
Chen Yi LI
1
;
Jia CHEN
1
;
Xiang Fan SHI
1
Author Information
1. Department of Medical Care for Cadres,Zhejiang Hospital,Hangzhou 310012,China.
- Publication Type:Journal Article
- MeSH:
Coronary Angiography;
Coronary Disease;
complications;
Humans;
Non-alcoholic Fatty Liver Disease;
complications;
Prevalence;
Prognosis;
Prospective Studies;
Risk Factors
- From:
Acta Academiae Medicinae Sinicae
2019;41(2):156-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the associations of non-alcoholic fatty liver disease(NAFLD)with the prevalence,severity,and prognosis of coronary heart disease(CHD). Methods A total of 512 hospitalized patients undergoing coronary angiography in our department from June 2013 to June 2015 were enrolled.Fatty liver was judged by ultrasound screening,and Gensini score was calculated according to the result of coronary angiography.Then the independent predictors of CHD were analyzed.The association between NAFLD and cardiovascular endpoints was analyzed during prospective follow-up among 276 CHD patients. Results The CHD prevalence was 76.8% in NAFLD group and 50.7% in non-NAFLD group(P=0.000),the number of target vessels was 2(1,3)and 1(1,3)(P=0.019),and the Gensini score was(29.02±27.62)and(24.04±20.18)(P=0.022),respectively.NAFLD was an independent predictor of CHD(OR=2.28,95%CI=1.54-3.56,P<0.001).The risk of cardiovascular endpoints was not significantly different between NAFLD group and non-NAFLD group(P>0.1).Cox regression analysis showed that NAFLD was not a predictor of cardiovascular endpoints in patients with CHD(HR=0.95,95%CI=0.62-1.58,P=0.691).Conclusion NAFLD is an independent predictor of CHD,and it is related to severity of coronary artery stenosis.However,it can not predict the clinical outcomes of patients with CHD.
