Energy Demand and Its Regulatory Mechanism during Folliculogenesis.
10.3881/j.issn.1000-503X.10774
- Author:
Hao Yan TU
1
;
Xiao Can LEI
2
;
Peng HUO
3
;
Jiang Hua LE
4
;
Shun ZHANG
1
Author Information
1. Department of Reproductive Medicine Center,Affiliated Hospital of Guilin Medical University,Guilin,Guangxi 541001,China.
2. School of Basic Medicine,Zunyi Medical University,Zunyi,Guizhou 563100,China.
3. School of Public Health, Affiliated Hospital,Guilin Medical University,Guilin,Guangxi 541001,China.
4. Department of Obestetrical,Affiliated Hospital,Guilin Medical University,Guilin,Guangxi 541001,China.
- Publication Type:Journal Article
- MeSH:
Energy Metabolism;
Female;
Glycolysis;
Granulosa Cells;
Humans;
Intercellular Signaling Peptides and Proteins;
Oocytes;
Ovarian Follicle;
growth & development;
Theca Cells
- From:
Acta Academiae Medicinae Sinicae
2019;41(3):408-414
- CountryChina
- Language:Chinese
-
Abstract:
The growth and development of follicles are regulated by genes,hormones and growth factors autocrined and paracrined from granulosa cells,theca cells,and oocytes.Products of glycolysis from granulosa cells such as pyruvate and lactate are one of the main energy sources,which play an important role during folliculogenesis and follicle maturity.Studies on the changes of the products and rate-limiting enzymes during granulosa cells' glycolysis help to clarify the molecular mechanism of energy demand in folliculogenesis and guide the clinical treatment of infertility due to abnormal follicular development.This article reviews recent research advances in the energy demand and regulatory mechanism in different states of folliculogenesis.
