Advances in the Apoptosis Repressor with Caspase Recruitment Domain in Cardiovascular Diseases.
10.3881/j.issn.1000-503X.10900
- Author:
Qi LI
1
;
Jun YANG
1
;
Jian YANG
1
;
Ying YANG
1
Author Information
1. Department of Cardiology,Institute of Cardiovascular Diseases,the First College of Clinical Medical Sciences,China Three Gorges University,Yichang,Hubei 443002,China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Apoptosis Regulatory Proteins;
physiology;
Cardiovascular Diseases;
Caspase Activation and Recruitment Domain;
Humans
- From:
Acta Academiae Medicinae Sinicae
2019;41(4):536-540
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis plays important roles in maintaining normal development and homeostasis and in the pathophysiological processes of various diseases.Previous studies have shown that cardiomyocyte apoptosis is involved in the development of various cardiovascular diseases.The apoptosis repressor with caspase recruitment domain(ARC)is abundantly expressed in heart,which makes ARC a unique and central cardioprotective factor via anti-apoptotic pathway.This article reviews the structure and characteristics of ARC as well as the roles and mechanisms of ARC in cardiovascular diseases.
