Exosomes in the Pathogenesis of Rheumatoid Arthritis.
10.3881/j.issn.1000-503X.10648
- Author:
Lei Hong DENG
1
;
Yun GONG
2
;
Xiao Lin HUANG
3
;
Hai Chao CHAO
4
Author Information
1. Department of Medicine,Graduate School,Nanchang University,Nanchang 330006,China.
2. Department of Endocrinology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China.
3. Department of Stomatology,School of Guizhou Medical University,Guiyang 550004,China.
4. Institute of Clinical Medicine,Jiangxi Province People's Hospital,Nanchang 330006,China.
- Publication Type:Journal Article
- MeSH:
Arthritis, Rheumatoid;
pathology;
Cell Communication;
Exosomes;
Humans;
Signal Transduction
- From:
Acta Academiae Medicinae Sinicae
2019;41(4):556-561
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are 30-100 nm vesicles secreted from almost all types of cells.They contain various molecular constituents,including proteins,lipids,and RNA.As important mediators of cell-to-cell communication,exosomes are involved in a variety of physiological and pathological processes such as inflammatory reaction,cell proliferation and differentiation,tissue repair,immune signal transduction,and stress response.Exosomes can regulate and maintain the initiation and progression of many autoimmune diseases,especially rheumatoid arthritis.Meanwhile,exosomes may be a new biomarker for the diagnosis of rheumatoid arthritis and a potential treatment vector for this disease.
