Gut Microbiome Differences between Gastrointestinal Cancer Patients and Healthy People.
10.3881/j.issn.1000-503X.11372
- Author:
Ning Ning LI
1
;
Chun Mei BAI
1
;
Lin ZHAO
1
;
Yu Ping GE
1
Author Information
1. Department of Medical Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100032,China.
- Publication Type:Journal Article
- Keywords:
cancer;
gastrointestinal neoplasms;
gut microbiome
- MeSH:
Bacteria;
classification;
Case-Control Studies;
Esophageal Neoplasms;
microbiology;
Esophageal Squamous Cell Carcinoma;
microbiology;
Feces;
microbiology;
Gastrointestinal Microbiome;
Humans;
RNA, Ribosomal, 16S;
genetics
- From:
Acta Academiae Medicinae Sinicae
2019;41(5):636-645
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the differences in fecal flora among patients with esophageal cancer,gastric cancer,or colorectal cancer and between patients with gastrointestinal tumors and healthy people.Methods The 16S rRNA method was used to analyze the differences in fecal flora among 13 patients with esophageal squamous cell carcinoma,23 patients with gastric cancer,6 patients with colorectal cancer,and 49 healthy persons.Results Bifidobacterium,,and were less abundant in the fecal flora of cancer patients than in those of healthy controls(all <0.05).Some species of and were significantly reduced in the feces of patients with esophageal cancer or gastric cancer than in healthy people(<0.05),whereas others showed consistency with the intestinal cancer group.Anti-tumor treatment,antibiotics,and lactic acid could affect the fecal flora of cancer patients.Conclusion The gut microbiota compositions(mainly and )and some specific bacteria species in the feces of patients with esophageal cancer and gastric cancer are similar to those in the feces of patients with intestinal cancer,suggesting these bacteria may be involved in the development of upper gastrointestinal tumors.
