Coagulation Disorders in Bullous Pemphigoid and Its Mechanism.
10.3881/j.issn.1000-503X.11698
- Author:
Tian Meng YAN
1
;
Ya Gang ZUO
2
Author Information
1. Department of Dermatology,The University of Hong Kong-Shenzhen Hospital,Shenzhen 518053,China.
2. Department of Dermatology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- Keywords:
anticoagulant system;
bullous pemphigoid;
coagulation;
fibrinolysis
- MeSH:
Autoantibodies;
Blister;
Blood Coagulation Disorders;
complications;
Blood Coagulation Factors;
Eosinophils;
Hemorrhage;
etiology;
Humans;
Mucous Membrane;
pathology;
Pemphigoid, Bullous;
complications;
Skin;
pathology;
Thrombosis;
etiology
- From:
Acta Academiae Medicinae Sinicae
2019;41(5):685-689
- CountryChina
- Language:Chinese
-
Abstract:
Bullous pemphigoid(BP)is an autoimmune blister disease caused by antibodies to the basement membrane zone.It usually exhibits tense bullae in skin and mucous membrane.BP patients can suffer from thrombosis due to hypercoagulation and/or hemorrhage due to the presence of anti-coagulation factors,which may be explained by the eosinophils,antibodies to the coagulation factors,and fibrinolytic system hyperactivity or inhibition.
