The study of salivary pepsin content and laryngopharyngeal reflux scale in 91 asymptomatic volunteers.
10.13201/j.issn.1001-1781.2018.06.005
- Author:
Mei Xiang CHEN
1
;
Chen Jie HOU
2
;
Ting CHEN
2
;
Yan Ping LI
2
;
Yan Ling ZENG
3
Author Information
1. Fujian Provincial Clinical College of Fujian Medical University, Fuzhou.
2. Department of Otorhinolaryngology, Fujian Provincial Hospital.
3. Department of Gastroenterology, Fujian Provincial Hospital.
- Publication Type:Journal Article
- Keywords:
asymptomatic volunteers;
laryngopharyngeal reflux;
reflux finding score;
salivary pepsin
- MeSH:
Humans;
Laryngopharyngeal Reflux;
diagnosis;
Laryngoscopy;
Pepsin A;
analysis;
Saliva;
chemistry;
Volunteers
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2018;32(6):415-419
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the content of pepsin in salivary, and to assess the laryngophargeal lesions based on the reflux founding score (RFS) scale in asymptomatic volunteers, in order to provide a reference for the diagnosis of laryngopharyngeal reflux.
METHODS:A total of 91 asymptomatic subjects were recruited in this study. Participants provided a fasting saliva specimen for pepsin measurement using enzyme-linked immunoadsorbent assay, completed the reflux symptom index (RSI) assessment and underwent laryngostroboscopic examination using a rigid endoscope. Their RFS were graded according to the laryngeal findings.
RESULTS:The median concentration of pepsin in 91 asymptomatic volunteers was 55.5 μg/L (range 3.53-191.64 μg/L). The mean individuals RSI was 2.24±2.34, and the mean individuals RFS was 5.78±1.74.
CONCLUSIONS:Our data demonstrate that certain concentration of pepsin was detected and showed a higher RFS score in asymptomatic volunteers.
