Expression of IL-25 and IL-33 and the count of EOS in peripheral blood of children with allergic rhinitis receiving immunotherapy.
10.13201/j.issn.1001-1781.2018.06.011
- Author:
Hua FAN
1
;
Tai Jie QIN
1
;
Lin Song YE
2
;
Feng Ti LI
2
;
Gan Sheng LIN
2
;
You Qiong LIANG
2
;
Shen Hong QU
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning.
2. Department of Otorhinolaryngology, the People's Hospital of Guangxi Zhuang Autonomuous Region.
- Publication Type:Journal Article
- Keywords:
IL-33;
IL-25;
eosinophils;
rhinitis, allergic
- MeSH:
Child;
Enzyme-Linked Immunosorbent Assay;
Eosinophils;
Humans;
Immunotherapy;
Interleukin-17;
metabolism;
Interleukin-33;
metabolism;
Rhinitis, Allergic;
immunology;
therapy
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2018;32(6):443-446
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the expression of IL-25,IL-33 and EOS in children with allergic rhinitis (AR).
METHODS:Ninety-four AR children receiving immunotherapy and 23 healthy people were concluded in the study. The serum levels of IL-25 and IL-33 were detected by Enzyme-linked Immunosorbent Assay (ELISA), and a count of EOS were measured.
RESULTS:The serum levels of IL-25 and IL-33 in the mild group were higher than control group (<0.05). The count of EOS showed no difference between the mild group and the control group (>0.05). The serum levels of IL-25 and IL-33 in the severe group were higher than those in mild group (<0.05). The serum levels of IL-25 and IL-33 in the severe group were higher than control group (<0.05). The count of EOS in the severe group were higher than those in mild group (<0.05). The count of EOS in the severe group were higher than those in control group (<0.05). Spearman test showed the serum levels of IL-25 in the children with AR patients have positive correlation with the serum levels of IL-33 (<0.05, =0.238).
CONCLUSIONS:Expression of IL-25 levels, IL-33 levels and the count of EOS in patients with AR are enhanced, which shows that IL-25, IL-33 and the count of EOS are involved in the AR. If we can understand the mechanism of them, it will profound implications for treatment.
