Expression and clinical significance of long non-coding RNA LINC00520 in laryngeal squamous cell carcinoma.
10.13201/j.issn.1001-1781.2018.02.003
- Author:
Yong Yan WU
1
;
Wei GAO
1
;
Yu Liang ZHANG
1
;
Min NIU
1
;
Jia Jia CUI
1
;
Cai Xia XIANG
1
;
Jiang Wei SANG
1
;
Shu Xin WEN
1
;
Bin Quan WANG
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China.
- Publication Type:Journal Article
- Keywords:
LINC00520;
laryngeal neoplasms;
long non-coding RNA;
tumor metastasis
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
pathology;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Prognosis;
RNA, Long Noncoding;
metabolism;
Up-Regulation
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2018;32(2):91-95
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of LINC00520 in laryngeal squamous cell carcinoma(LSCC),and analyze its relevance and roles in carcinogenesis and development of LSCC.The expression of LINC00520 in laryngeal squamous cell carcinoma tissue and paired adjacent normal tissue was determined by real-time PCR.The relationship between the expression of LINC00520 and the clinicopathological characteristics including clinical stage,pathological type,histological grade and lymph node metastasis of LSCC was analyzed.(1)The LINC00520 expression level was significantly upregulated in LSCC tissues compared to that of paired adjacent normal tissues(<0.000 1).(2)There were no statistical differences of the LINC00520 expression level among supraglottic,glottic and subglottic LSCCs(>0.05).The LINC00520 expression level had no significant changes in poorly differentiated LSCC compared with that of well and moderately differentiated counterparts(>0.05).Moreover,the expression of LINC00520 had no significant difference between T1+T2 stage and T3+T4 stage LSCC tissues(>0.05).Interestingly,the LINC00520 level in LSCC with lymph node metastasis was significantly higher than that in patients without lymph node metastasis(<0.01).Upregulation of LINC00520 in LSCC may contribute to its metastasis.
