Clinical and laboratory characteristics of hematopathy with t(5;12)(q33;p13) translocation.
10.3760/cma.j.issn.1003-9406.2018.06.025
- Author:
Siping WANG
1
;
Li LI
;
Jianxiang WANG
Author Information
1. Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China. wangjx@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Chromosomes, Human, Pair 12;
genetics;
Chromosomes, Human, Pair 5;
genetics;
Hematologic Neoplasms;
genetics;
Humans;
In Situ Hybridization, Fluorescence;
Karyotyping;
Male;
Retrospective Studies;
Translocation, Genetic
- From:
Chinese Journal of Medical Genetics
2018;35(6):879-882
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical and laboratory characteristics of hematopoietic tumor with t(5;12)(q33;p13). To sum up the similarities and differences of these diseases.
METHODS:The chromosome samples were prepared by short-term training of bone marrow cells, and the karyotype analysis was carried out by R or G band. Using PDGFRb dual color fracture rearrangement probe and fluorescence in situ hybridization (FISH) technology to detect the rearrangement of the gene, the immune-typing analysis was performed using flow cytometry. For 7 cases with t(5;12)(q33;p13) patients with hematopathy were retrospectively analyzed.
RESULTS:Seven patients were diagnosed with different diagnoses, mainly male. Nuclear type analysis 5 cases of t(5;12)(q33;p13) was of primary abnormality and 2 cases of secondary abnormality. Five of the seven patients were treated and two untreated. Among the treatment patients, two cases were fatal, two case was lost and one case was treated with combined chemotherapy with dasatinib targeted therapy. The treatment process was successful and is still in hospital.
CONCLUSION:With t (5;12) (q33;p13) blood system tumors are rare and have unique clinical and laboratory characteristics. At the same time, the heterogeneity is obvious, the patients with tyrosine kinase inhibitor combined with chemotherapy have good effect and good prognosis, and the prognosis of chemotherapy alone is poor.
