Association of single nucleotide polymorphisms of rs3819024 and rs8193037 loci of IL-17A gene with the risk of ischemic stroke.
10.3760/cma.j.issn.1003-9406.2018.06.026
- Author:
Huatuo HUANG
1
;
Rong WANG
;
Yulan LU
;
Chunfang WANG
;
Haimei QIN
;
Yang XIANG
;
Hongcheng LUO
;
Junli WANG
;
Lanqing MENG
;
Yesheng WEI
Author Information
1. Department of Laboratory Medicine, the Affiliated Hospital of Youjiang Medical University, Baise, Guangxi 533000, China. yeshengwei22@163.com.
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian Continental Ancestry Group;
Brain Ischemia;
genetics;
Case-Control Studies;
China;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Interleukin-17;
genetics;
Polymorphism, Single Nucleotide;
Stroke;
genetics
- From:
Chinese Journal of Medical Genetics
2018;35(6):883-886
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the association of polymorphisms of rs3819024 and rs8193037 loci in the promoter region of IL-17A gene with the risk of ischemic stroke (IS) among ethnic Han Chinese from Guangxi.
METHODS:The polymorphisms of rs3819024 and rs8193037 loci were detected by a SNaPshot assay and DNA sequencing among 392 IS patients and 443 healthy controls with matched age and gender.
RESULTS:The genotypes, dominant model, recessive model, and alleles of rs3819024 polymorphisms showed no significant difference between the two groups, with the P values calculated as 0.150, 0.227, 0.125, 0.594 and 0.202, respectively, and OR (95% CI) as 1.27(0.92-1.74), 1.28(0.86-1.91), 1.27(0.94-1.72), 1.10(0.78-1.54), and 1.13(0.94-1.38), respectively. The genotypes, dominant model, recessive model, and alleles of rs8193037 polymorphisms also showed no significant difference between the two groups, with the P values calculated as 0.722, 0.352, 0.863, 0.345 and 0.969, respectively, and OR (95% CI) as 0.94(0.65-1.35), 2.25(0.41-12.35), 0.97(0.68-1.38), 2.27(0.41-12.48), and 1.01(0.72-1.40), respectively.
CONCLUSION:Polymorphisms of the rs3819024 and rs8193037 loci of the IL-17A gene are not associated with the susceptibility to IS among ethnic Han Chinese from Guangxi.
