Study of genetic polymorphisms of 7 Y chromosome single nucleotide polymorphism loci among Mongolians from Inner Mongolia Region.
10.3760/cma.j.issn.1003-9406.2018.06.031
- Author:
Li LI
1
;
Xiaoyan YOU
;
Mingxia ZHONG
;
Lei WANG
;
Weizhe LI
;
Zhaoshu ZENG
Author Information
1. Department of Obstetrics and Gynecology, Central Hospital of Zhengzhou, Zhengzhou, Henan 450007, China. zzs@zzu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
China;
Chromosomes, Human, Y;
genetics;
Gene Frequency;
Genetics, Population;
Haplotypes;
Humans;
Male;
Polymorphism, Single Nucleotide
- From:
Chinese Journal of Medical Genetics
2018;35(6):901-903
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the genetic polymorphisms of 7 Y chromosome single nucleotide polymorphisms (Y-SNPs) among unrelated Mongolian males from Inner Mongolia Region.
METHODS:Seven Y-SNPs with expected allelic frequencies close to 0.50:0.50 in Mongolian population were selected from databases including HapMap and relevant literature. The Y-SNPs were then analyzed among 95 unrelated male Mongolian DNA samples with ligase detection reaction (LDR) technique. Statistical analysis was carried out with Arlequin 3.5.
RESULTS:All of the 7 Y-SNPs had 2 alleles. Seven haplotypes were identified among the 95 samples, with the haplotype diversity (HD) being 0.7990. Except for rs17316007, whose allelic frequencies was 0.832:0.168, each of the remaining Y-SNPs had a allelic frequency close to 0.50:0.50. The gene diversity (GD) for rs17316007 was 0.2825, while those of the remaining Y-SNPs were all greater than 0.4375.
CONCLUSION:Except for rs17316007, the other 6 Y-SNPs showed good diversity and genetic polymorphism, and may be used for individual identification and paternity testing for the Inner Mongolia region.
