Role of Tbx20 gene in the development of cardiac valves.
10.3760/cma.j.issn.1003-9406.2018.06.032
- VernacularTitle:Tbx20基因在心脏瓣膜发育中的作用
- Author:
Juan GONG
1
;
Fang LIU
Author Information
1. Children's Hospital of Fudan University, Shanghai 201102, China. liufanga@fudan.edu.cn.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
Cell Proliferation;
Gene Expression Regulation, Developmental;
Gene Regulatory Networks;
Heart Valves;
embryology;
Humans;
T-Box Domain Proteins;
genetics
- From:
Chinese Journal of Medical Genetics
2018;35(6):904-907
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac valves are highly organized yet delicate structures that ensure unidirectional blood flow through the cardiac chambers and large vessels. Disturbed development of cardiac valves can lead to aberrant heart formation and function which account for approximately one third of congenital heart diseases. The formation of cardiac valves is a dynamic process accomplished by a series of complex events including lineage determination and cell proliferation, differentiation and migration. This paper reviews current knowledge about the role of Tbx20 gene in the development of cardiac valves, which include functional diversities of Tbx20 at various stages of cardiac valve development, its interaction with other signaling pathways, and genetic network involved in endocardial development.
