Genetic polymorphisms of 23 autosomal short tandem repeat loci among ethnic Han Chinese from southern China.
10.3760/cma.j.issn.1003-9406.2019.02.020
- VernacularTitle:中国南方汉族23个常染色体短串联重复基因座的遗传多态性
- Author:
Yaqing ZHANG
1
;
Chao YANG
;
Sen CHEN
;
Ying'ai ZHANG
Author Information
1. Institute of Blood Transfusion, Blood Center of Hainan Province, Haikou, Hainan 570311, China. mwfandmwf@sina.com.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
China;
Gene Frequency;
Genetics, Population;
Genotype;
Humans;
Microsatellite Repeats;
Polymorphism, Genetic
- From:
Chinese Journal of Medical Genetics
2019;36(2):171-174
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study genetic polymorphisms of 23 autosomal short tandem repeat (STR) loci among ethnic Han Chinese from southern China.
METHODS:The 23 autosomal STR loci among 331 unrelated healthy Han Chinese from southern China were genotyped with fluorescent multiplex amplification and capillary electrophoresis. Genetic parameters were subjected to statistical analysis.
RESULTS:In total 265 alleles and 890 genotypes were detected for the 23 STR loci. The numbers of alleles were 5-22, allelic frequency was 0.0015-0.5483, heterozygosity was 0.5891-0.9124, power of discrimination was 0.7818-0.9831, polymorphic information content was 0.5425-0.9031, probability of exclusion for trio-paternity testing was 0.2780-0.8208, and probability of exclusion for duo-paternity testing was 0.193-0.693. The combined power of discrimination was over 0.999 999 999 999 99, the combined probability of exclusion for trio-paternity identification was 0.999 999 999 729 813, and the combined probability of exclusion for duo-paternity identification was 0.999 999 207 508 474, respectively. The 23 STR loci showed no significant deviation from Hardy-Weinberg disequilibrium after Bonferroni correction (P> 0.05).
CONCLUSION:The 23 autosomal STR loci were highly polymorphic among ethnic Han Chinese from southern China, which showed a high efficiency for paternity testing, personal identification and population genetics.
