Analysis of Genetic Screening in Couples of Reproductive Age for Thalassemia in Lingshui Li Autonomous County of Hainan Province.
10.19746/j.cnki.issn.1009-2137.2019.04.038
- Author:
Zhi-Hua TU
1
;
Zhi ZHOU
1
;
Wei-Xue WU
2
;
Xiao-Peng WANG
3
;
Yang-Zhi ZHOU
3
;
Ci-Dan HUANG
4
;
Ning MA
1
;
Hai-Ling RUAN
1
;
Li-Qiang ZHAO
1
;
Jie WANG
5
Author Information
1. Center for Reproductive Medicine, Hainan Provincial Maternal and Child Health Hospital, Haikou 570206, Hainan Province, China.
2. Grassroots Guidance Section, Hainan Provincial Maternal and Child Health Hospital, Haikou 570206, Hainan Province, China.
3. Department of Clinical Laboratorial Examination, Lingshui Li Autonomous County, Lingshui 5724000, Hainan Province, China.
4. Center of Laboratorial Examination, Hainan Provincial Maternal and Child Health Hospital Haikou, 570206, Hainan Province, China.
5. Center of Laboratorial Examination, Hainan Provincial Maternal and Child Health Hospital Haikou, 570206, Hainan Province, China,E-mail: yelaixiang7899@163.com.
- Publication Type:Journal Article
- MeSH:
China;
Genetic Testing;
Genotype;
Heterozygote;
Humans;
alpha-Thalassemia;
beta-Thalassemia
- From:
Journal of Experimental Hematology
2019;27(4):1227-1231
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the genetic carrier rate of thalassemia and its gene mutation types as well as the distribution characteristics among the people in Lingshui Li autonomous county of Hainan province, so as to provide the basis for making the prevention programs of thalassemia in administrative departments.
METHODS:Samples were collected from couples undergoing premarital and pregestational screenings, in which the positive ones in preliminary screening were further tested by genetic diagnoses and the genotypes were analyzed.
RESULTS:The rate of thalassemia gene carriers was 19.41% （274/1412） of the couples of childbearing age in Lingshui Li autonomous County of Hainan Province. In these carriers,α-thalassemia accounted for 83.21%（228/274）, β-thalassemia for 8.03%（22/274）, and both α-and β-thalassemia gene accounted for 8.76% （28/274）.
CONCLUSION:The carrying rate of thalassemia gene in population Lingshui Li autonomous county of Hainan province is high, and its distribution has geographical characteristics,the major type is α-thalassemia. Blood screening and genetic diagnosis of thalassemia should be strengthened, and corresponding measures should be taken to reduce its gene frequency.
