Research Progress on Immune Mechanism of Immune Thrombocytopenia--Review.
10.19746/j.cnki.issn.1009-2137.2019.04.054
- Author:
Wei-Qi HUANG
1
;
Yong-Ming ZHOU
2
Author Information
1. Department of Hematology，The Tianyou Hospital Affiliated to Wuhan University of Science and Technology，Wuhan 430064，Hubei Province，China.
2. Department of Hematology，The Tianyou Hospital Affiliated to Wuhan University of Science and Technology，Wuhan 430064，Hubei Province，China E-mail: zhym112@126.com.
- Publication Type:Journal Article
- MeSH:
Cytokines;
Humans;
Interleukin-4;
Purpura, Thrombocytopenic, Idiopathic;
Th17 Cells
- From:
Journal of Experimental Hematology
2019;27(4):1321-1324
- CountryChina
- Language:Chinese
-
Abstract:
Abstract Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease, although the ITP pathogenesis is completely unknown, but in terms of the current view, the immune tolerance is main reason for the onset of ITP. In recent years, more and more immune cell subsets, cytokines and the new approacher were found to be closely related with the ITP, such as saliva acid, B cell activating factor, dysfunction of regulatory B cells and Th1/Th2 balance drift, CD4 CD25 T cell function defect, IL-23/Th17 pathway regulation, etc., In this paper, the latest research progress on the immune pathogenesis of ITP are reviewed, so as to provide theoretical basis and research direction for further understanding the pathogenesis of ITP.
