Mutation and Clinical Feature of IL-7R in Adult Patients with Acute Lymphoblastic Leukemia.
10.19746/j.cnki.issn.1009-2137.2019.05.010
- Author:
Guo-Mei FU
1
;
Dan-Dan CHEN
1
;
Chuan WU
1
;
Meng WANG
1
;
Zheng-Xi PAN
1
;
Xue-Yang PENG
1
;
Hui SUN
1
;
Ling SUN
1
;
Yan-Fang LIU
1
;
Zhong-Xing JIANG
2
Author Information
1. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhenzhou 450052, Henan Province, China.
2. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhenzhou 450052, Henan Province, China,E-mail：jiangzx313@126.com.
- Publication Type:Journal Article
- MeSH:
Adult;
Female;
Humans;
Interleukin-7 Receptor alpha Subunit;
genetics;
Male;
Mutation;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Signal Transduction
- From:
Journal of Experimental Hematology
2019;27(5):1416-1423
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the IL-7R gene mutation and clinical features of adult patients with acute lymphoblastic leukemia (ALL).
METHODS:One hundred sixty-four cases of newly treated adults with ALL from May 2016 to December 2018 were selected. Targeted and specific next-generation sequencing technology was used to detected a total of 16 types of Ph-like ALL mutations, which include IL-7R mutation, and the cilinical features, rate, types and sites of IL-7R were analyzed.
RESULTS:IL-7R mutation was determined in 10 cases of 164 adult patients with ALL and the total mutation frequency was 13 times (6.1%). Out of 10 cases 5 cases were male (50%), 5 cases were female (50%). 6 cases of B-ALL ( 60% ) and 4 cases of T-ALL (40%). The mutation site of all cases was located at exon 6, among which 6 cases had replacement mutations, 3 cases had deletion mutations and 4 cases had insertion mutations. In addition, 1 triple and 1 double mutation of IL-7R were found. Besides, six mutation sites were newly identified, including: c.720_724del, c.723_726del, c.721_722insAGTG, c.727_728insTAACGGCCCCCTGCT, c.727_728insATGCAGGGAGCGAA and c.728_729insAAGTGTCA.
CONCLUSION:Six novel mutation sites and a poor manifestation of IL-7R have been explored in this research. Thus more samples are required to study the effects of IL-7R mutation on ALL treatment.
