Curative Effect of Simply Hormone and Combined Gamma Globulin and Thrombopoietin on Primary Immune Thrombocytopenia.
10.19746/j.cnki.issn.1009-2137.2019.05.040
- Author:
You-Jun HONG
1
;
Guo-Qi ZHOU
2
Author Information
1. Department of Hematology, The First People's Hospital of Wuhu, Wuhu 241000, Anhui Province, China.
2. Department of Hematology, The First People's Hospital of Wuhu, Wuhu 241000, Anhui Province, China,E-mail:hongyoujuntg@126.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Immunoglobulins, Intravenous;
Purpura, Thrombocytopenic, Idiopathic;
Thrombopoietin;
gamma-Globulins
- From:
Journal of Experimental Hematology
2019;27(5):1617-1621
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the curative effect of simply hormone and combined gamma globulin and thrombopoietin(TPO) on primary immune thrombocytopenia(PITP).
METHODS:100 patients with PITP were divided into simply drug groups, and combined drug group each for 50 cases. The patients in single drug group were given simply hormone therapy, the patients in combined drug group were given gamma globulin and thrombopoietin. The levels of TPO, platelet activating factor (PAF) were detected by DAS-ELISA. The differences of clinical curative effect, clinical indicators, biochemical indexes and adverse reactions between the two groups were compared.
RESULTS:The total effective rate of combined drug group (90.00%) was obviously higher than that in single drug group (66.00%)(P<0.05). Amount of platelet infusion in combined drug group was obviously less than that in single drug group, platelet recovery time and effect onset time in combined drug group were significantly shorter than those in single drug group, and the maintaining time in combined drug group was obviously longer than that in single drug group. At the same time, the platelet peak in combined drug group was higher than that in single drug group (P<0.05). The levels of TPO, PAF between the two groups did not show statisticall significant differences before treatment (P>0.05), however, the above-mentioned indexes of two groups after treatment were lower than those before treatment (P<0.05), among them, the indexes in combined drug group were obviously lower ttan those in sigle drug group (P<0.05). The adverse reaction and mortality rate between the two groups did not show statistically significant differences(P>0.05), the recurrence rate in combined drug group(2%) was obviously lower than that in single group(14.00%) (P<0.05).
CONCLUSION:The curative effect of hormone, as well as gamma globulin combined with TPO to treat PITP are satisfying, can obviously improve the levels of TPO, PAF, and the drug safety is higher. but the efficacy of combined drug is surperior to single drug.
