Post-translational Modifications of PML in Regulating the Functions of Nuclear Bodies --Review.
10.19746/j.cnki.issn.1009-2137.2019.05.052
- Author:
Xue-Fei MA
1
;
Yun TAN
1
;
Shu-Fen LI
1
;
Wen JIN
1
;
Kan-Kan WANG
2
Author Information
1. State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
2. State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China E-mail: kankanwang@shsmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Intranuclear Inclusion Bodies;
Leukemia, Promyelocytic, Acute;
Nuclear Proteins;
Promyelocytic Leukemia Protein;
Protein Processing, Post-Translational
- From:
Journal of Experimental Hematology
2019;27(5):1696-1700
- CountryChina
- Language:Chinese
-
Abstract:
Abstract The promyelocytic leukemia (PML) gene encoded PML protein as a tumor suppressor protein, plays important roles in the occurrence and development of various cancers including acute promyelocytic leukemia. Recent studies have indicated that there are a variety of post-translational modifications of the PML protein, such as SUMOylation, ubiquitination, phosphorylation, and acetylation in cells. These modifications of the PML protein can directly affect the formation of PML nuclear bodies (PML-NBs), repair DNA damage, and modulate cell apoptosis. Furthermore, the abnormal modifications of PML not only result in the occurrence of hematopoietic tumors, but also are closely related to the drug-resistance of cancer. Therefore, investigating the post-translational modifications of PML is significant to uncover the mechanism of formation and functions of PML-NBs, thus contributing to the prevention and treatment of related hematopoietic tumors. In this review, the characteristics of the post-translational modifications of PML protein and the relationship between these modifications and functions of PML-NBs are summarized so as to provide the potential targets for the treatment of related cancers.
