Research Advances on the Pathogenesis of Primary Immune Thrombocytopenia--Review.
10.19746/j.cnki.issn.1009-2137.2019.05.054
- Author:
Yong-Ping YUAN
1
;
Xiang YANG
1
;
Yi-Jian CHEN
2
Author Information
1. Gannan Medical College Ganzhou 341000, Jiangxi Province,China.
2. Department of Hematology, The First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province,China E-mail：chenyj2005@163.com.
- Publication Type:Journal Article
- MeSH:
ADAM10 Protein;
Blood Platelets;
Humans;
Platelet Count;
Purpura, Thrombocytopenic, Idiopathic
- From:
Journal of Experimental Hematology
2019;27(5):1706-1710
- CountryChina
- Language:Chinese
-
Abstract:
Abstract Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by less than 100×10/L platelet count in peripheral blood. The pathogenesis of ITP is complex and has not been fully elucidated. Currently, researches on the pathogenesis of ITP mainly focus on the disorders of humoral immunity and cellular immunity. In recent years, some new progress has been made in the study of this pathogenesis, including the platelet clearance pathway that is not dependent on Fc γ R mediation, the metalloproteinase (ADAM) 10 that can regulate T and B cells, and the abnormal expression of micro RNA in genetic factors. Under the joint action of multiple factors, the imbalance of the immune system in the body leads to the occurrence of ITP. This article reviews the research progress on humoral immunity, cellular immunity and other possible new pathogenesis of ITP in recent years.
