A Meta-Analysis of Efficacy and Adverse Effects of Lobaplatin and Cisplatin in the Treatment of Malignant Pleural Effusion.
10.3779/j.issn.1009-3419.2019.02.03
- Author:
Shihui MIN
1
;
Qiangqiang ZHENG
1
;
Bailu ZHANG
1
;
Danli YAN
1
;
Rulan WANG
1
;
Zihan QU
1
;
Lu LI
1
;
Jiewei LIU
1
;
Qinghua ZHOU
1
Author Information
1. Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
Cisplantin;
Lobaplatin;
Malignant pleural effusion;
Meta-analysis
- MeSH:
Antineoplastic Agents;
adverse effects;
therapeutic use;
Cisplatin;
adverse effects;
therapeutic use;
Cyclobutanes;
adverse effects;
therapeutic use;
Humans;
Organoplatinum Compounds;
adverse effects;
therapeutic use;
Pleural Effusion, Malignant;
drug therapy;
Randomized Controlled Trials as Topic
- From:
Chinese Journal of Lung Cancer
2019;22(2):90-98
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The aim of this study is to systematically evaluate the efficacy and adverse effects of Lobaplatin and Cisplatin in the treatment of malignant pleural effusion.
METHODS:The databases of Medline (PubMed), Embase, Web of Science, Cochrane, Wanfang, CNKI and VIP were retrieved so as to search the studies about the randomized controlled clinical trials (RCT) that compared the Lobaplatin and Cisplatin for malignant pleural effusion. The main outcome indicators include objective response rate, complete response, partial response, nephrotoxicity, chest pain, gastrointestinal reaction, myelosuppression, fever response and hepatotoxicity. Relative risk was used as the effect size, which was expressed as 95% confidence interval. The meta-analysis was performed using Stata 14.0 statistical software.
RESULTS:A total of 12 RCTs and 720 MPE patients were included. The results showed that the ORR (RR=1.27, 95%CI: 1.15-1.40, P<0.001), CR (RR=1.39, 95%CI: 1.09-1.78, P=0.007), PR (RR=1.21, 95%CI: 1.02-1.42, P=0.026) in LBP thoracic perfusion chemotherapy were significantly higher than those in DDP thoracic perfusion chemotherapy. The incidence of nephrotoxicity (RR=0.31, 95%CI: 0.13-0.71, P=0.005) and gastrointestinal reactions (RR=0.44, 95%CI: 0.31-0.62, P<0.001) in the LBP group were significantly lower than those in DDP group.
CONCLUSIONS:Compared with DDP pleural perfusion chemotherapy, the ORR, CR and PR of LBP pleural perfusion chemotherapy for MPE are significantly better than DDP, and its nephrotoxicity and gastrointestinal reactions are remarkably lower than DDP.
