Application of Metabolic Parameters Measured by ¹⁸F-FDG PET/CT in the Evaluation of the Prognosis of Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2019.03.09
- Author:
Tao WANG
1
;
Zhenguang WANG
1
Author Information
1. Department of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao 266100, China.
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Metabolic parameters;
Prognostic evaluation
- MeSH:
Carcinoma, Non-Small-Cell Lung;
diagnostic imaging;
metabolism;
Fluorodeoxyglucose F18;
Humans;
Image Processing, Computer-Assisted;
Lung Neoplasms;
diagnostic imaging;
metabolism;
Positron Emission Tomography Computed Tomography;
methods;
Prognosis
- From:
Chinese Journal of Lung Cancer
2019;22(3):167-172
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-node-metastasis (TNM) staging system is the most important basis for making therapeutic decisions and predicting prognosis of lung cancer patients. The metabolic parameters including standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by ¹⁸F-fluorodeoxyglucose-positron emission tomography (¹⁸F-FDG PET/CT) associate with tumor aggressiveness and can provide additional prognostic information. A new staging methodology combines the conventional cTNM with the metabolic tumor burden quantified from the PET images is a better predictor of overall survival with superior stratifying power may help oncologists to make better treatment plans. ¹⁸F-FDG PET/CT image texture analysis, as an emerging research tool, is used to quantify the spatial heterogeneity of radioactive uptake in tumors, thereby to explore the biological characteristics of the tumor. This article reviews developments in evaluating the ¹⁸F-FDG PET/CT metabolic parameters and its role as a prognostic factor for non-small cell lung cancer.
.
