Expression and Clinical Significance of Cancer-derived Immunoglobulin G in Non-small Cell Lung Cancer by Bioinformatics and Immunohistochemistry.
10.3779/j.issn.1009-3419.2019.06.03
- Author:
Guohui WANG
1
,
2
,
3
;
Xiongtao YANG
1
,
2
,
3
;
Guangying ZHU
1
,
2
,
3
Author Information
1. Peking University China-Japan Friendship School of Clinical Medicine
2. Department of Radiation Oncology, Center of Respiratory Medicine,China-Japan Friendship Hospital
3. National Clinical Research Center for Respiratory Diseases, Beijing 100000, China.
- Publication Type:Journal Article
- Keywords:
Cancer-IgG;
Lung neoplasms;
Mechanism;
Prognosis
- MeSH:
Adult;
Aged;
Biomarkers, Tumor;
metabolism;
Carcinoma, Non-Small-Cell Lung;
genetics;
metabolism;
pathology;
Carrier Proteins;
genetics;
metabolism;
Computational Biology;
Female;
Humans;
Immunoglobulin G;
genetics;
metabolism;
Immunohistochemistry;
Lung Neoplasms;
genetics;
metabolism;
pathology;
Male;
Middle Aged;
Neoplasm Staging;
Young Adult
- From:
Chinese Journal of Lung Cancer
2019;22(6):341-348
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:It was believed that immunoglobulin G (IgG) was synthesized only by B cells. However, in recent years, researchers have found that a variety of cancer cells can also synthesize IgG (cancer-IgG) which promote the development of tumors. This study analyzed the expression and clinical significance of cancer-IgG in non-small cell lung cancer (NSCLC), and initially explored its mechanism.
METHODS:The expression of IgG1 heavy chain gamma 1 (IGHG1) and cancer-IgG were detected by bioinformatics and immunohistochemistry in NSCLC; The gene set enrichment analysis (GSEA) method was used to explore the signaling pathways involved in IGHG1 regulation.
RESULTS:The expression level of cancer-IgG in NSCLC was significantly higher than that in normal tissues. The high expression group had a poor prognosis and was associated with clinical stage (P=0.042), T stage (P=0.044) and metastasis (P=0.007). GSEA analysis showed that IGHG1 was associated with cell adhesion, cytokine interaction and chemokine signaling pathway.
CONCLUSIONS:High expression of cancer-IgG in NSCLC is a poor prognosis factor, which may be related to the promotion of tumor invasion and metastasis.
