Effects of Electrical Field Stimulation of the Isolated Corpus Cavernosum from Hypertensive Rats.
- Author:
Yang Il PARK
1
;
Ju Hyun OH
;
Kwang Sung PARK
;
Jong Kun LEE
Author Information
1. Department of Urology, Chonnam University Medical School, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
electrical field stimulation(EFS);
hypertension;
nitric oxide(NO)
- MeSH:
Animals;
Atropine;
Baths;
Guanethidine;
Hypertension;
Kidney;
NG-Nitroarginine Methyl Ester;
Nitric Oxide;
Phenylephrine;
Rats*;
Relaxation
- From:Korean Journal of Urology
1996;37(10):1075-1079
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present study was aimed to investigate whether and to what extent hypertension affects the relaxation of the corpus cavernosum. The corpus cavernosum was isolated from 12-week 2- kidney, 1-clip hypertensive rats. The corporal strips were isolated and suspended longitudinally in an organ bath. They were precontracted with phenylephrine, and their responses to electrical field stimulation (EFS) were examined. EFS caused a frequency-dependent contraction (60%) or relaxation (40%) of the corpus cavernosum precontracted with phenylephrine. The contraction response was inhibited or abolished and only frequency-dependent relaxation appeared in the presence of atropine (0.00001mol/L) and guanethidine (0.00001mol/L). The relaxation response to EFS of the corporal preparation precontracted with phenylephrine was attenuated or abolished in the presence of L-NAME (0.0001mol/L). The corporal preparation from the hypertensive rats also showed a frequency-dependent relaxation, however, the degree of which was lower at a low frequency of stimulation than that from the normotensive control. These results suggest that endothelium-derived nitric oxide released upon neural stimulation partly mediate the relaxation of the corpus cavernosum. It is also suggested that hypertension is associated with a partly attenuated relaxation response to EFS.
