Development of Blood Flow and Oxygen Monitoring System for Mice Based on Laser Speckle and Spectrum.
10.3969/j.issn.1671-7104.2019.01.001
- Author:
Yuemei ZHAO
1
;
Yanbai XUE
1
;
Yan ZHANG
1
;
Weitao LI
1
;
Zhiy QIAN
1
Author Information
1. Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106.
- Publication Type:Journal Article
- Keywords:
brain injury;
laser speckle;
simultaneous monitoring;
spectral analysis
- MeSH:
Algorithms;
Animals;
Blood Gas Analysis;
instrumentation;
Brain;
Cerebrovascular Circulation;
Lasers;
Mice;
Oxygen;
analysis
- From:Chinese Journal of Medical Instrumentation
2019;43(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
simultaneous monitoring of blood flow and changes of concentration of oxyhemoglobin (ΔHbO) in brain is a key important method for the research of cerebrovascular disease. In this study, a new monitoring system, combining laser speckle contrast imaging method and spectral analysis method, was proposed, which could be utilized to measure the cerebral blood flow and ΔHbO on mice during traumatic brain injury. The principle of the present system was studied and the hardware platform of the detection system was built. Then, user interface software and algorithms were implemented based on Labview and Matlab software. Finally, the performance of the present system was verified by the experiments.
