The Relationship of Cellular Composition of Benign Prostatic Hyperplasia and Prostate-Specific Antigen (PSA) Levels.
- Author:
Byung Ha CHUNG
1
;
Bong Hyeon LEE
;
Sung Joon HONG
Author Information
1. Department of Urology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
prostate specific antigen;
benign prostatic hyperplasia;
tissue composition
- MeSH:
Densitometry;
Humans;
Male;
Prostate;
Prostate-Specific Antigen*;
Prostatic Hyperplasia*
- From:Korean Journal of Urology
1996;37(10):1093-1096
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The relationship between the serum values of prostate-specific antigen (PSA) and the histologic composition of benign prostatic hyperplasia (BPH) was investigated in 32 symptomatic BPH patients undergoing transurethral resection of the prostate. We evaluated the free and total PSA concentrations by ACS-PSA2 (Ciba-Corning) assay. The stereological analysis was made by computer aided-area densitometry using H & E stained slides to quantify stromal and glandular areas in the resected prostate tissue. The total PSA concentration versus percentage of glandular area (%G) and stromal-glandular ratio (SGR) correlated significantly (p<0.05 for both) whereas the free PSA concentration and free/total PSA ratio did not (p>0.05 for both). These data suggest that total PSA is directly correlated with the histologic composition of the prostate in men with BPH, however, the proportion of free to total PSA was not informative to predict the histology. Thus, pretreatment evaluation of total PSA would be useful as part of an evaluation method of BPH for medical therapy.
