Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness.
10.1007/s12264-018-0250-6
- Author:
Ping CHEN
1
;
Qiuyou XIE
2
;
Xiaoyan WU
1
;
Huiyuan HUANG
1
;
Wei LV
2
;
Lixiang CHEN
1
;
Yequn GUO
2
;
Shufei ZHANG
1
;
Huiqing HU
1
;
You WANG
3
;
Yangang NIE
4
;
Ronghao YU
5
;
Ruiwang HUANG
6
Author Information
1. Center for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, China.
2. Centre for Hyperbaric Oxygen and Neurorehabilitation, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.
3. Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
4. School of Education, Guangzhou University, Guangzhou, 510006, China.
5. Centre for Hyperbaric Oxygen and Neurorehabilitation, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010, China. gesund@21cn.com.
6. Center for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, China. ruiwang.huang@gmail.com.
- Publication Type:Journal Article
- Keywords:
Basal ganglia;
Connectome-based predictive modeling;
Mesocircuit;
Posterior cingulate cortex;
Spectral dynamic causal modeling
- MeSH:
Adult;
Bayes Theorem;
Connectome;
Consciousness Disorders;
diagnostic imaging;
physiopathology;
Female;
Humans;
Machine Learning;
Magnetic Resonance Imaging;
Male;
Middle Aged;
Neural Pathways;
diagnostic imaging;
physiopathology;
Prognosis;
Prosencephalon;
diagnostic imaging;
physiopathology;
Young Adult
- From:
Neuroscience Bulletin
2018;34(4):647-658
- CountryChina
- Language:English
-
Abstract:
A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.
