White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness.
10.1007/s12264-018-0253-3
- Author:
Xuehai WU
1
;
Jiaying ZHANG
2
;
Zaixu CUI
2
;
Weijun TANG
3
;
Chunhong SHAO
4
;
Jin HU
1
;
Jianhong ZHU
1
;
Yao ZHAO
1
;
Lu LU
5
;
Gang CHEN
6
;
Georg NORTHOFF
7
;
Gaolang GONG
8
;
Ying MAO
9
;
Yong HE
2
Author Information
1. Neurosurgical Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.
2. State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
3. Radiological Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.
4. Psychiatry Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.
5. Huajia Hospital, Shanghai, 200438, China.
6. Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA.
7. Institute of Mental Health Research, University of Ottawa, Ottawa, ON, K1Z 7K4, Canada.
8. State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. gaolang.gong@bnu.edu.cn.
9. Neurosurgical Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China. maoying@fudan.edu.cn.
- Publication Type:Journal Article
- Keywords:
Brain injury;
Diffusion tensor imaging;
Disorder of consciousness;
White matter
- MeSH:
Adult;
Brain Stem;
diagnostic imaging;
Consciousness;
physiology;
Consciousness Disorders;
diagnostic imaging;
pathology;
Diffusion Tensor Imaging;
methods;
Female;
Humans;
Image Processing, Computer-Assisted;
methods;
Male;
Middle Aged;
White Matter;
pathology;
physiopathology
- From:
Neuroscience Bulletin
2018;34(4):668-678
- CountryChina
- Language:English
-
Abstract:
In this study, we aimed to (1) identify white matter (WM) deficits underlying the consciousness level in patients with disorders of consciousness (DOCs) using diffusion tensor imaging (DTI), and (2) evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest (ROIs), and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.
