Spinal Cord Stimulation Frequency Influences the Hemodynamic Response in Patients with Disorders of Consciousness.
10.1007/s12264-018-0252-4
- Author:
Juanning SI
1
;
Yuanyuan DANG
2
;
Yujin ZHANG
3
;
Yaxin LI
1
;
Wenyue ZHANG
1
;
Yi YANG
2
;
Yue CUI
3
;
Xiaoping LOU
1
;
Jianghong HE
4
;
Tianzi JIANG
5
Author Information
1. School of Instrumentation Science and Opto-electronics Engineering, Beijing Information Science and Technology University, Beijing, 100192, China.
2. Department of Neurosurgery, People's Liberation Army General Hospital, Beijing, 100700, China.
3. Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
4. Department of Neurosurgery, People's Liberation Army General Hospital, Beijing, 100700, China. he_jianghong@sina.cn.
5. Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. jiangtz@nlpr.ia.ac.cn.
- Publication Type:Journal Article
- Keywords:
Disorder of consciousness;
Frequency;
Functional near-infrared spectroscopy;
Hemodynamic response;
Spinal cord stimulation
- MeSH:
Adolescent;
Adult;
Brain;
physiopathology;
Consciousness;
physiology;
Consciousness Disorders;
physiopathology;
therapy;
Female;
Hemodynamics;
physiology;
Humans;
Male;
Middle Aged;
Pilot Projects;
Spinal Cord;
physiopathology;
surgery;
Spinal Cord Stimulation;
methods;
Young Adult
- From:
Neuroscience Bulletin
2018;34(4):659-667
- CountryChina
- Language:English
-
Abstract:
Spinal cord stimulation (SCS) is a promising technique for treating disorders of consciousness (DOCs). However, differences in the spatio-temporal responsiveness of the brain under varied SCS parameters remain unclear. In this pilot study, functional near-infrared spectroscopy was used to measure the hemodynamic responses of 10 DOC patients to different SCS frequencies (5 Hz, 10 Hz, 50 Hz, 70 Hz, and 100 Hz). In the prefrontal cortex, a key area in consciousness circuits, we found significantly increased hemodynamic responses at 70 Hz and 100 Hz, and significantly different hemodynamic responses between 50 Hz and 70 Hz/100 Hz. In addition, the functional connectivity between prefrontal and occipital areas was significantly improved with SCS at 70 Hz. These results demonstrated that SCS modulates the hemodynamic responses and long-range connectivity in a frequency-specific manner (with 70 Hz apparently better), perhaps by improving the cerebral blood volume and information transmission through the reticular formation-thalamus-cortex pathway.
