Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness.
10.1007/s12264-018-0260-4
- Author:
Xiaoyu WANG
1
;
Rao FU
1
;
Xiaoyu XIA
2
;
Xueling CHEN
2
;
Han WU
3
;
Nicole LANDI
4
;
Ken PUGH
4
;
Jianghong HE
5
;
Fengyu CONG
6
Author Information
1. School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, 116024, China.
2. Department of Neurosurgery, People's Liberation Army General Hospital, Beijing, 100700, China.
3. Faculty of Linguistic Science, Beijing Language and Culture University, Beijing, 100083, China.
4. Haskins Laboratory, Yale University, New Haven, CT, 06511, USA.
5. Department of Neurosurgery, People's Liberation Army General Hospital, Beijing, 100700, China. he_jianghong@sina.cn.
6. School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, 116024, China. cong@dlut.edu.cn.
- Publication Type:Journal Article
- Keywords:
Disorder of consciousness;
EEG;
Minimally conscious state;
Mismatch negativity;
Vegetative state
- MeSH:
Acoustic Stimulation;
Adolescent;
Adult;
Aged;
Auditory Perception;
physiology;
Brain Injuries;
complications;
physiopathology;
Consciousness Disorders;
etiology;
physiopathology;
Electroencephalography;
Evoked Potentials;
Female;
Humans;
Male;
Middle Aged;
Neuropsychological Tests;
Severity of Illness Index;
Wavelet Analysis
- From:
Neuroscience Bulletin
2018;34(4):700-708
- CountryChina
- Language:English
-
Abstract:
In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of frequency-deviant stimulus (standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity (MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery Scale-Revised (CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions (small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location (frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness.
