Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke.
10.1007/s12264-018-0266-y
- Author:
Shengxiang LIANG
1
;
Xiaofeng JIANG
2
;
Qingqing ZHANG
3
;
Shaofeng DUAN
4
;
Tianhao ZHANG
4
;
Qi HUANG
4
;
Xi SUN
1
;
Hua LIU
4
;
Jie DONG
1
;
Weilin LIU
3
;
Jing TAO
3
;
Shujun ZHAO
5
;
Binbin NIE
6
;
Lidian CHEN
3
;
Baoci SHAN
4
Author Information
1. College of Physical Science and Technology, Zhengzhou University, Zhengzhou, 450001, China.
2. School of Public Health and Family Medicine, Capital Medical University, Beijing, 100068, China.
3. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
4. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
5. College of Physical Science and Technology, Zhengzhou University, Zhengzhou, 450001, China. zhaosj@zzu.edu.cn.
6. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. niebb@ihep.ac.cn.
- Publication Type:Journal Article
- Keywords:
Acute;
FDG PET;
Ischemic stroke;
Metabolic connectivity
- MeSH:
Acute Disease;
Animals;
Brain;
diagnostic imaging;
metabolism;
Brain Mapping;
Disease Models, Animal;
Fluorodeoxyglucose F18;
Glucose;
metabolism;
Infarction, Middle Cerebral Artery;
diagnostic imaging;
metabolism;
Male;
Neural Pathways;
diagnostic imaging;
metabolism;
Positron-Emission Tomography;
Radiopharmaceuticals;
Random Allocation;
Rats, Sprague-Dawley
- From:
Neuroscience Bulletin
2018;34(5):715-724
- CountryChina
- Language:English
-
Abstract:
Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion (MCAO) at the acute stage using F-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO. Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together, the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research.
