Altered Neuronal Activity in the Central Nucleus of the Amygdala Induced by Restraint Water-Immersion Stress in Rats.
10.1007/s12264-018-0282-y
- Author:
Feng HE
1
;
Hongbin AI
2
;
Min WANG
2
;
Xiusong WANG
2
;
Xiwen GENG
3
Author Information
1. Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, 250014, China. fengheysn@163.com.
2. Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, 250014, China.
3. Advanced Materials Genome Innovation Team, Advanced Materials Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
- Publication Type:Journal Article
- Keywords:
Central nucleus of the amygdala;
Corticotropin-releasing hormone;
Gastric ulceration;
Neuronal activity;
Restraint water-immersion stress
- MeSH:
Action Potentials;
drug effects;
physiology;
Analysis of Variance;
Animals;
Central Amygdaloid Nucleus;
pathology;
Corticotropin-Releasing Hormone;
metabolism;
Disease Models, Animal;
Gastric Mucosa;
pathology;
Gene Expression Regulation;
physiology;
Neurons;
physiology;
Patch-Clamp Techniques;
Proto-Oncogene Proteins c-fos;
metabolism;
Rats;
Rats, Wistar;
Stress, Physiological;
physiology;
Stress, Psychological;
etiology;
physiopathology
- From:
Neuroscience Bulletin
2018;34(6):1067-1076
- CountryChina
- Language:English
-
Abstract:
Restraint water-immersion stress (RWIS), a compound stress model, has been widely used to induce acute gastric ulceration in rats. A wealth of evidence suggests that the central nucleus of the amygdala (CEA) is a focal region for mediating the biological response to stress. Different stressors induce distinct alterations of neuronal activity in the CEA; however, few studies have reported the characteristics of CEA neuronal activity induced by RWIS. Therefore, we explored this issue using immunohistochemistry and in vivo extracellular single-unit recording. Our results showed that RWIS and restraint stress (RS) differentially changed the c-Fos expression and firing properties of neurons in the medial CEA. In addition, RWIS, but not RS, induced the activation of corticotropin-releasing hormone neurons in the CEA. These findings suggested that specific neuronal activation in the CEA is involved in the formation of RWIS-induced gastric ulcers. This study also provides a possible theoretical explanation for the different gastric dysfunctions induced by different stressors.
