Pericyte Plasticity in the Brain.
10.1007/s12264-018-0296-5
- Author:
Gabryella S P SANTOS
1
;
Luiz A V MAGNO
2
;
Marco A ROMANO-SILVA
2
;
Akiva MINTZ
3
;
Alexander BIRBRAIR
4
Author Information
1. Departamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
2. Department of Mental Health, Federal University of Minas Gerais, Belo Horizonte, MG, 30130-100, Brazil.
3. Department of Radiology, Columbia University Medical Center, New York, NY, 10032, USA.
4. Departamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. birbrair@icb.ufmg.br.
- Publication Type:Journal Article
- Keywords:
Blood vessel;
Brain;
Pericytes;
Plasticity
- MeSH:
Animals;
Brain;
blood supply;
physiology;
physiopathology;
Brain Diseases;
physiopathology;
Capillaries;
physiology;
Cellular Microenvironment;
Diabetic Retinopathy;
physiopathology;
Endothelial Cells;
physiology;
Humans;
Pericytes;
physiology;
Vascular Remodeling
- From:
Neuroscience Bulletin
2019;35(3):551-560
- CountryChina
- Language:English
-
Abstract:
Cerebral pericytes are perivascular cells that stabilize blood vessels. Little is known about the plasticity of pericytes in the adult brain in vivo. Recently, using state-of-the-art technologies, including two-photon microscopy in combination with sophisticated Cre/loxP in vivo tracing techniques, a novel role of pericytes was revealed in vascular remodeling in the adult brain. Strikingly, after pericyte ablation, neighboring pericytes expand their processes and prevent vascular dilatation. This new knowledge provides insights into pericyte plasticity in the adult brain.
