Altered Local Field Potential Relationship Between the Parafascicular Thalamic Nucleus and Dorsal Striatum in Hemiparkinsonian Rats.
10.1007/s12264-018-0312-9
- Author:
Haiyan ZHANG
1
;
Jing YANG
1
;
Xuenan WANG
1
;
Xiaomeng YAO
1
;
Hongyu HAN
1
;
Yunfeng GAO
1
;
Hongli CHANG
2
;
Tianyu XIANG
1
;
Shuang SUN
1
;
Yanan WANG
1
;
Xiusong WANG
3
;
Min WANG
4
Author Information
1. Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Jinan, 250014, China.
2. School of Physics and Electronics, Shandong Normal University, Jinan, 250014, China.
3. Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Jinan, 250014, China. wangxiusong@sdnu.edu.cn.
4. Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Jinan, 250014, China. wangmin@sdnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Dorsal striatum;
Local field potential;
Parafascicular thalamic nucleus;
Parkinson’s disease;
Synchronization
- MeSH:
Animals;
Brain Waves;
physiology;
Corpus Striatum;
physiopathology;
Cortical Synchronization;
physiology;
Dopaminergic Neurons;
physiology;
Electrocorticography;
Male;
Neural Pathways;
physiopathology;
Oxidopamine;
Parkinsonian Disorders;
physiopathology;
Rats, Wistar;
Thalamic Nuclei;
physiopathology;
Walking;
physiology
- From:
Neuroscience Bulletin
2019;35(2):315-324
- CountryChina
- Language:English
-
Abstract:
The thalamostriatal pathway is implicated in Parkinson's disease (PD); however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex (CM/Pf, or the Pf in rodents) and the dorsal striatum (DS) remain unclear. Therefore, we simultaneously recorded local field potentials (LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band (12 Hz-35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta (0.5 Hz-3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition, exaggerated low gamma (35 Hz-70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta (3 Hz-7 Hz) and beta bands, and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha (7 Hz-12 Hz) and beta bands for two coherence measures. Collectively, dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease.
