Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population.
10.1007/s12264-018-0323-6
- Author:
Chao LUO
1
;
Junyan LIU
2
;
Xu WANG
1
;
Xiaoyuan MAO
1
;
Honghao ZHOU
1
;
Zhaoqian LIU
3
Author Information
1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
2. Department of Orthopaedics, The First Affiliated Hospital of the University of South China, Hengyang, 421001, China.
3. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China. liuzhaoqian63@126.com.
- Publication Type:Journal Article
- Keywords:
Antipsychotic;
Pharmacogenetic;
Schizophrenia;
Single nucleotide polymorphism;
Weight gain
- MeSH:
Antipsychotic Agents;
adverse effects;
Asian Continental Ancestry Group;
genetics;
China;
Genome-Wide Association Study;
Genotype;
Humans;
Lipid Metabolism;
genetics;
Neurosecretory Systems;
drug effects;
Pharmacogenomic Testing;
Polymorphism, Single Nucleotide;
Receptors, Adrenergic;
genetics;
Receptors, Dopamine;
genetics;
Receptors, Histamine;
genetics;
Receptors, Serotonin;
genetics;
Weight Gain;
drug effects;
genetics
- From:
Neuroscience Bulletin
2019;35(3):561-580
- CountryChina
- Language:English
-
Abstract:
Antipsychotic-induced weight gain (AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. We determined that > 25 single-nucleotide polymorphisms in 19 genes have been investigated in association with AIWG in Chinese patients over the past few decades. HTR2C rs3813929 is the most frequently studied single-nucleotide polymorphism, and it seems to be the most strongly associated with AIWG in the Chinese population. However, many genes that have been reported to be associated with AIWG in other ethnic populations have not been included in Chinese studies. To explain the pharmacogenetic reasons for AIWG in the Chinese population, genome-wide association studies and multiple-center, standard, unified, and large samples are needed.
