Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats.
10.1007/s12264-018-00333-w
- Author:
Xinzhi WANG
1
;
Shuyue LI
2
;
Jinbang MA
1
;
Chuangang WANG
1
;
Anzhong CHEN
3
;
Zhenxue XIN
4
;
Jianjun ZHANG
5
Author Information
1. Department of Neurosurgery, The Second People's Hospital of Liaocheng, Linqing, 252601, China.
2. Department of Internal Medicine, The Second People's Hospital of Liaocheng, Linqing, 252601, China.
3. Department of Rehabilitation Medicine, The Second People's Hospital of Liaocheng, Linqing, 252601, China.
4. Department of Neurosurgery, The Second People's Hospital of Liaocheng, Linqing, 252601, China. zhenxuexin_lcey@163.com.
5. Department of Neurosurgery, The Second People's Hospital of Liaocheng, Linqing, 252601, China. jianjunzhang_lcey@163.com.
- Publication Type:Journal Article
- Keywords:
Early brain injury;
Gastrodin;
Neuronal apoptosis;
Neuroprotection;
Subarachnoid hemorrhage
- MeSH:
Animals;
Apoptosis;
drug effects;
Astrocytes;
drug effects;
metabolism;
Benzyl Alcohols;
administration & dosage;
Blood-Brain Barrier;
drug effects;
metabolism;
Brain;
drug effects;
metabolism;
Brain Edema;
etiology;
prevention & control;
Calcium;
metabolism;
Glucosides;
administration & dosage;
Glutamic Acid;
metabolism;
Male;
Microglia;
drug effects;
metabolism;
Neurons;
drug effects;
Neuroprotective Agents;
administration & dosage;
Oxidative Stress;
drug effects;
Rats, Sprague-Dawley;
Subarachnoid Hemorrhage;
complications;
metabolism;
prevention & control
- From:
Neuroscience Bulletin
2019;35(3):461-470
- CountryChina
- Language:English
-
Abstract:
Gastrodin is a phenolic glycoside that has been demonstrated to provide neuroprotection in preclinical models of central nervous system disease, but its effect in subarachnoid hemorrhage (SAH) remains unclear. In this study, we showed that intraperitoneal administration of gastrodin (100 mg/kg per day) significantly attenuated the SAH-induced neurological deficit, brain edema, and increased blood-brain barrier permeability in rats. Meanwhile, gastrodin treatment significantly reduced the SAH-induced elevation of glutamate concentration in the cerebrospinal fluid and the intracellular Ca overload. Moreover, gastrodin suppressed the SAH-induced microglial activation, astrocyte activation, and neuronal apoptosis. Mechanistically, gastrodin significantly reduced the oxidative stress and inflammatory response, up-regulated the expression of nuclear factor erythroid 2-related factor 2, heme oxygenase-1, phospho-Akt and B-cell lymphoma 2, and down-regulated the expression of BCL2-associated X protein and cleaved caspase-3. Our results suggested that the administration of gastrodin provides neuroprotection against early brain injury after experimental SAH.
