Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice.
10.1007/s12264-018-0322-7
- Author:
Fengfeng LU
1
;
Dou YIN
1
;
Yingyan PU
2
;
Weili LIU
1
;
Zhenghao LI
2
;
Qi SHAO
2
;
Cheng HE
3
;
Li CAO
4
Author Information
1. Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
2. Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.
3. Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China. chenghe@smmu.edu.cn.
4. Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China. caoli@smmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Demyelination;
Oligodendrocyte precursor cells;
Remyelination;
Shikimic acid
- MeSH:
Animals;
Apoptosis;
drug effects;
Cell Differentiation;
drug effects;
Cell Proliferation;
drug effects;
Cells, Cultured;
Demyelinating Diseases;
prevention & control;
Encephalitis;
prevention & control;
Encephalomyelitis, Autoimmune, Experimental;
prevention & control;
Female;
Mice, Inbred C57BL;
Myelin Basic Protein;
metabolism;
Neuroprotective Agents;
administration & dosage;
Oligodendrocyte Precursor Cells;
drug effects;
metabolism;
Rats;
Remyelination;
drug effects;
Shikimic Acid;
administration & dosage;
TOR Serine-Threonine Kinases;
metabolism
- From:
Neuroscience Bulletin
2019;35(3):434-446
- CountryChina
- Language:English
-
Abstract:
The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas of demyelination. Thus, promoting the differentiation of OPCs is vital for the treatment of demyelinating diseases. Shikimic acid (SA) is mainly derived from star anise, and is reported to have anti-influenza, anti-oxidation, and anti-tumor effects. In the present study, we found that SA significantly promoted the differentiation of cultured rat OPCs without affecting their proliferation and apoptosis. In mice, SA exerted therapeutic effects on experimental autoimmune encephalomyelitis (EAE), such as alleviating clinical EAE scores, inhibiting inflammation, and reducing demyelination in the CNS. SA also promoted the differentiation of OPCs as well as their remyelination after lysolecithin-induced demyelination. Furthermore, we showed that the promotion effect of SA on OPC differentiation was associated with the up-regulation of phosphorylated mTOR. Taken together, our results demonstrated that SA could act as a potential drug candidate for the treatment of demyelinating diseases.
