Chemistry and biology research on bitter-taste Chinese materia medica with function of regulating glycolipid metabolism.
10.19540/j.cnki.cjcmm.20180709.006
- Author:
Fang-Jin LU
1
;
Li-Qin DING
2
;
Shi-Jie CAO
2
;
De-Qin ZHANG
2
;
Bo-Li ZHANG
2
;
Feng QIU
1
Author Information
1. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
2. Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
- Publication Type:Journal Article
- Keywords:
biological activity;
bitter-taste Chinese materia medica;
chemical composition;
diabetes;
signaling pathway;
the regulation of glucose and lipid metabolism
- MeSH:
Glycolipids;
metabolism;
Materia Medica;
chemistry;
Medicine, Chinese Traditional;
Research;
Taste
- From:
China Journal of Chinese Materia Medica
2018;43(19):3834-3840
- CountryChina
- Language:Chinese
-
Abstract:
The bitter taste is one of the important properties among five flavors of Chinese materia medica (CMM), characterized by downbearing and discharging, drying dampness, and consolidating Yin. In common CMM, bitter-taste CMM accounts for a large proportion, indicating the importance of it. Through the efficacy of clearing away heat and dampness, reducing fire and removing toxin, bitter-taste CMM has achieved good results in treating diabetes in clinical application, proving their definite therapeutic effect on regulating glucose and lipid metabolism (main features of diabetes). At present, there are many reports about the chemical constituents and pharmacological effects of CMM on diabetes, but there are few reviews on the chemistry and biology of bitter-taste CMM. This study summarized the properties and compatibility characteristics of bitter-taste CMM for treating diabetes, and mainly analyzed the chemistry and biology basis of bitter-taste CMM with function of regulating glycolipid metabolism, laying foundation for further researches on properties theory of CMM.
