A new naphthaldehyde derivative from Comastoma pulmonarium and its anti-tobacco mosaic virus (anti-TMV) activity.
10.19540/j.cnki.cjcmm.20180807.009
- Author:
Xiao-Long WANG
1
;
Ping LI
1
;
Jing LI
2
;
Jian-Hua CHEN
2
;
Guang-Yu YANG
2
;
Qiu-Fen HU
1
;
Cheng-Ming ZHANG
2
;
Gan-Peng LI
1
Author Information
1. Key Laboratory of Chemistry in Ethnic Medicinal Resource, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650500, China.
2. Technology Center, China Tobacco Yunnan industrial Co., Ltd., Kunming 650106, China.
- Publication Type:Journal Article
- Keywords:
Comastoma pulmonarium;
anti-tobacco mosaic virus activity;
naphthaldehyde
- MeSH:
Aldehydes;
isolation & purification;
pharmacology;
Antiviral Agents;
isolation & purification;
pharmacology;
Chromatography, High Pressure Liquid;
Gentianaceae;
chemistry;
Naphthalenes;
isolation & purification;
pharmacology;
Phytochemicals;
isolation & purification;
pharmacology;
Tobacco;
Tobacco Mosaic Virus;
drug effects
- From:
China Journal of Chinese Materia Medica
2018;43(19):3884-3886
- CountryChina
- Language:Chinese
-
Abstract:
A new naphthaldehyde derivative has been isolated from Comastoma pulmonarium by using various chromatographic techniques, including silica gel, Sephadex LH-20, MCI-gel resin and RP-HPLC. This compounds was determined as 5-methoxy-2-methyl-7-(2-oxopropyl)naphthalene-1-carbaldehyde(1) by NMR, MS, IR and UV spectra. This compound was also evaluated for its anti-tobacco mosaic virus (anti-TMV) activity. The result showed that it showed high anti-TMV activity with inhibition rate of 32.8%. The inhibition rate is close to that of positive control (ningnanmycin).
