A Case of Premature Ovarian Failure Assosiated with Gonadal Dysgenesis.
- Author:
Sook Hwan LEE
;
Tae Ki YOON
;
Kwang Yul CHA
;
Yoon Sung NAM
;
In Pyung KWAK
- Publication Type:Case Report
- Keywords:
Premature ovarian failure;
Gonadal dysgenesis
- MeSH:
Centromere;
Clinical Medicine;
Female;
Gonadal Dysgenesis*;
Gonads*;
Humans;
Karyotype;
Primary Ovarian Insufficiency*;
Y Chromosome
- From:Korean Journal of Obstetrics and Gynecology
1999;42(1):138-141
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Prenature ovarian failure is a condition causing amenarrhea, hypoestrogenism, and elevated genadotropins in women younger than 40 years. A karyotype should be performed as part of basic laboratory evaluation for all patients with premature ovarian failure and prodromal premature ovarian failure. Development of a malignancy in a dysgenetic gonad is of major concern. The presence of a fragment of the Y chromosome is thought to be a key to the oncogenic potential of these gonads. The search for the testicular determining factor(TDF) has engendered much confusion about which part of the Y chromosome plays a role in malignancy. This was initially postulated to be the H- Y antigen. More recent data, however, localize the area near the centromere of the Y Chromosome, on the long arm(Yq). Malignant potential is clearly not linked to the testicular determining factor itself(SRY). This is a critical point in clinical medicine. Feilure to display SRY or a closely related sequence does not rule out the presence of the segment of the Y chromosome postulated to be associated with the development of malignancies. We have experienced a case of premature ovarian failure with chtomosomal abnormality involving Y chromosome fragment. So we report this case with a brief review of literatures.
