Effect of long-term intake of ginseng extracts on gut microbiota in rats.
10.19540/j.cnki.cjcmm.20180604.001
- Author:
Yi-Fan SUN
1
;
Xia ZHANG
1
;
Xiao-Yan WANG
1
;
Wei JIA
1
Author Information
1. Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
- Publication Type:Journal Article
- Keywords:
ginseng extracts;
ginsenosides;
gut microbiota;
probiotics
- MeSH:
Animals;
Bacteria;
classification;
China;
Gastrointestinal Microbiome;
drug effects;
Panax;
chemistry;
Plant Extracts;
pharmacology;
Rats
- From:
China Journal of Chinese Materia Medica
2018;43(19):3927-3932
- CountryChina
- Language:Chinese
-
Abstract:
As a traditional Chinese medicine in China, ginseng has a wide range of medicinal and health value. At present, the nutritional value of ginseng as a medicinal food has been a hotspot in studies. Intestinal flora plays an important role in the organism, which has been confirmed by many researchers. In order to find out the effect of long-term intake of ginseng extracts on the gut microbiota structure of rats, MiSeq sequencing platform was applied in macro gene sequencing of cecal contents in the long-term use of ginseng extracts modelin rats. According to the findings, after long-term administration with ginseng extracts, probiotics such as Bifidobacterium, Lactobacillus, Allobaculum and Clostridium, in the intestinal flora of rats were significantly increased, suggesting that long-term intake of ginseng extracts could facilitate the growth of probiotics. Meanwhile, some pathogenic bacteria, such as Butyricimonas, Parabacteroides, Alistipes, Helicobacter, were significantly down-regulated, indicating that long-term intake of ginseng extracts may have a positive effect in inhibiting the colonization of pathogenic bacteria. In conclusion, this study provided an important basis for the research on the effect of long-term use of ginseng extracts on the intestinal flora of rats.
